【摘要】 目的制备醋酸戈舍瑞林缓释微球,考察其一般性质和体外释药特性。方法采用复乳-液中干燥法制备醋酸戈舍瑞林微球,测定微球的外观形态、粒度分布和体外释药曲线。结果微球形态规则,粒径约为85.6μm,微球体外释药规律符合Higuchi方程:Q=16.202t1/2+1.550 3,r=0.991 0。结论制备的醋酸戈舍瑞林微球具有长时间的缓释作用。更多还原

【Abstract】 Objective To prepare goserelin acetate sustained-release microspheres and investigate their general and in vitro properties.Methods Goserelin acetate microspheres were prepared by double emulsion-drying in liquid.The morphology,particle size distribution and in vitro release curve were measured.Results The shape of microshperes was normal,and diameters of all particles were about 85.6 μm.The in vitro release profile was figured by Higuchi equation: Q = 16.202 t1/2 + 1.550 3,r= 0.991 0.Conclusion The prepared goserelin acetate microspheres have long-time sustained-release effect.更多还原